Triacetoxyperiodinane → 6-Fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carbaldehyde

HRID 1593607ノート

反応式

HRID 1593607 の反応式
CC(OI1(OC(C)=O)(OC(C)=O)[O:14][C:12](=O)[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]1=2)=O.[F:23][C:24]1[CH:25]=[C:26]2[C:34](=[CH:35][CH:36]=1)[NH:33]C1CC(C(NC[C@@H]3OC4=C5C(=CC=C4OC3)N=C(C)C=C5)=O)CCC2=1>ClCCl>[F:23][C:24]1[CH:36]=[C:35]2[C:34](=[CH:26][CH:25]=1)[NH:33][C:8]1[CH2:7][CH2:6][CH:11]([CH:12]=[O:14])[CH2:10][C:9]2=1

参加物

4

反応物 2

HCID 159087Triacetoxyperiodinane2 回HCID 866076466-fluoro-N-{[(2S)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}-2,3,4,9-tetrahydro-1H-carbazole-2-carboxamide

生成物 1

HCID 251395066-Fluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carbaldehyde収率 47%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Dess-Martin periodinane (7.37 g, 17.4 mmol) was added portion-wise to a stirred solution/suspension of alcohol II (2.64 g, 11.8 mmole) in dichloromethane (120 mL). The alcohol completely dissolved after the Dess-Martin reagent was added. The reaction mixture was stirred at ambient temperature for 30 min, and then quenched with ethanol. The reaction mixture was diluted with ether (860 mL) and washed twice with saturated aqueous sodium bicarbonate (550 mL) followed by 5% sodium thiosulfate pentahydrate. After washing with brine and drying (MgSO4), the solvent was evaporated to give a residue which was purified by chromatography on silica gel eluting with hexane/ethyl acetate (4:1). Compound V was obtained in 47% yield (1.2 g). mp: 96-98° C. MS: [M−H]− @m/z=216.1.

後処理

  1. additionwas added
  2. customquenched with ethanol
  3. additionThe reaction mixture was diluted with ether (860 mL)
  4. washwashed twice with saturated aqueous sodium bicarbonate (550 mL)
  5. washAfter washing with brine
  6. dry with materialdrying (MgSO4)
  7. customthe solvent was evaporated
  8. customto give a residue which
  9. customwas purified by chromatography on silica gel eluting with hexane/ethyl acetate (4:1)

出典と根拠

ORDレコード
ord-cd53a95173c14b25a8103823a30b658d
出典データセット
uspto-grants-2007_11
特許番号
US07297704B2

反応ノート

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