Hydrochloric Acid → 8-Fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thiophene-2-carboxylic acid

HRID 1593617ノート

反応式

HRID 1593617 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]3[CH2:10][CH2:11][CH:12]([C:14]([O:16]CC)=[O:15])[CH2:13][C:7]=3[C:6]=2[CH:19]=1.[OH-].[K+].Cl.O>CCO>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]3[CH2:10][CH2:11][CH:12]([C:14]([OH:16])=[O:15])[CH2:13][C:7]=3[C:6]=2[CH:19]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 69235740Ethyl 8-fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thiophene-2-carboxylate

生成物 1

HCID 692352028-Fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thiophene-2-carboxylic acid収率 96%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

To a solution of ethyl 8-fluoro-1,2,3,4-tetrahydrodibenzo[b,d]thiophene-2-carboxylate (2.5 g, 9 mmol) in EtOH (60 mL) was added KOH (0.81 g, 15 mmol). The reaction was stirred at 40° C. overnight. After cooling in an ice-water bath, the mixture was acidified to pH 2-3 with 1 N HCl. Water was added and the resulting white solid precipitate was collected and dried to afford 2.15 g (96%) of the title compound: mp 245° C. (dec.), MS (−) 249 (M−H)−.

後処理

  1. temperatureAfter cooling in an ice-water bath
  2. customthe resulting white solid precipitate was collected
  3. customdried

出典と根拠

ORDレコード
ord-7cc9e1ec658c4b528687701fb5afb218
出典データセット
uspto-grants-2007_11
特許番号
US07297704B2

反応ノート

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