Bromobenzene → 1-Pentadecyl-3-phenoxybenzene

関与物質

反応条件

反応手順

To a round bottom flask containing 111 g potassium salt of 3-pentadecylphenol (0.32 mol) was added 50.88 g (0.32 mol) of bromobenzene, followed by 2.22 g Cu powder (2 wt %) along with 150 ml N,N-dimethylacetamide. The reaction mixture was then heated at 150° C. for 8 hours. After completion of the reaction the obtained dark colored solution was poured into 500 ml water; the Cu salts were removed by filtration; The filtrate was extracted with ethyl acetate, thoroughly washed with water followed by saturated aqueous sodium chloride solution and dried over sodium sulfate. Solvent evaporation yielded crude 1-pentadecyl-3-phenoxy benzene. Pure 1-pentadecyl-3-phenoxy benzene was obtained after silica gel (60-120 mesh) column chromatography (pet ether) 70 g (57% of the theoretical).

情報源と証拠