Piperazine → Ethyl 2-(piperazin-1-yl)-1,3-thiazole-5-carboxylate

HRID 1594003ノート

反応式

HRID 1594003 の反応式
Br[C:2]1[S:3][C:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:6]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>C(O)C>[N:12]1([C:2]2[S:3][C:4]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:6]=2)[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

参加物

4

反応物 2

HCID 4837PiperazineHCID 3614103Ethyl 2-bromothiazole-5-carboxylate

生成物 1

HCID 54595879Ethyl 2-(piperazin-1-yl)-1,3-thiazole-5-carboxylate収率 93%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.02 g (5.0 mmol) of ethyl 2-bromothiazole-5-carboxylate and 4.31 g (50 mmol) of piperazine were dissolved in ethanol (20 ml) and the mixture was heated under reflux over a period of 4 h. The solution was then concentrated in vacuo, taken up in EA and washed successively with water and a satd aq. NaCl solution. Following drying of the organic phase over MgSO4, filtration and removal of solvent in vacuo there were obtained 1.12 g (4.6 mmol, 93%) of ethyl 2-piperazin-1-ylthiazole-5-carboxylate.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux over a period of 4 h
  3. concentrationThe solution was then concentrated in vacuo
  4. washwashed successively with water
  5. dry with materialFollowing drying of the organic phase over MgSO4, filtration and removal of solvent in vacuo

出典と根拠

ORDレコード
ord-6b095b5db6f74b3ab4a55b43fd34cf20
出典データセット
uspto-grants-2007_11
特許番号
US07300939B2

反応ノート

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