Hydrochloric Acid → 3-(n-((2-(2-Carboxyphenyl)phenyl)carbonyl)-n-(2-(4-ethoxyphenyl)ethyl)amino)propanoic acidethyl ester

HRID 1594185ノート

反応式

HRID 1594185 の反応式
ClC1C=CC(CNC(C2C=CC=CC=2C2C=CC=CC=2C([N:24]([CH2:35][CH2:36][C:37]([OH:39])=[O:38])[CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2OC)=O)=O)=CC=1.[C:42]12[C:49]3=[CH:50][CH:51]=[CH:52][CH:53]=[C:48]3[C:47](=[O:54])[O:46][C:44](=[O:45])[C:43]1=[CH:55][CH:56]=[CH:57][CH:58]=2.[CH2:59](N(CC)CC)[CH3:60].Cl.[C:67](OCC)(=[O:69])[CH3:68]>C(Cl)Cl>[CH2:59]([O:39][C:37](=[O:38])[CH2:36][CH2:35][N:24]([C:47]([C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][C:49]=1[C:42]1[CH:58]=[CH:57][CH:56]=[CH:55][C:43]=1[C:44]([OH:46])=[O:45])=[O:54])[CH2:25][CH2:26][C:27]1[CH:28]=[CH:29][C:30]([O:69][CH2:67][CH3:68])=[CH:31][CH:32]=1)[CH3:60]

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 72794Diphenic anhydrideHCID 230791343-(n-((2-(2-((4-Chlorobenzylamino)carbonyl)phenyl)phenyl)carbonyl)-n-(2-(2-methoxyphenyl)ethyl)amino)propanoic acid

生成物 1

HCID 692464633-(n-((2-(2-Carboxyphenyl)phenyl)carbonyl)-n-(2-(4-ethoxyphenyl)ethyl)amino)propanoic acidethyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The compound prepared in reference example 1 (600 mg), diphenic anhydride (538 mg) and triethylamine (0.85 ml) were dissolved in methylene chloride (10 ml) and the mixture was stirred overnight at room temperature. The reaction mixture was poured into a mixture of ethyl acetate and 1N hydrochloric acid, and the aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with a saturated aqueous solution of sodium bicarbonate and brine successively and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (837 mg) having the following physical data.

後処理

  1. extractionthe aqueous layer was extracted with ethyl acetate
  2. washThe combined organic layer was washed with a saturated aqueous solution of sodium bicarbonate and brine successively
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-2eeb114e530a41dfb41d22137bc8dde7
出典データセット
uspto-grants-2007_11
特許番号
US07300917B2

反応ノート

読み込み中…