Hydrochloric Acid → (-)-1-Methyl-3-phenylpropylamine

反応式

COCC([NH:6][C@H:7]([CH3:16])[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=O.Cl>>[CH3:16][C@@H:7]([NH2:6])[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 23627162HCID 23627162、化合物

生成物 1

HCID 2734033(-)-1-Methyl-3-phenylpropylamine収率 100.2%

実験手順

This gives 7.4 g (96.25 % ee, 84% of theory) of (R)-N-methoxyacetyl-1-methyl-3-phenyl-propylamine, which is then heated under reflux with 50 ml of 18% strength aqueous hydrochloric acid for 4 hours. Work-up gives 5.0 g (96% ee, 98% of theory) of (R)-1-methyl-3-phenyl-propylamine.

出典と根拠

ORDレコード: ord-02cc6d23d55f4629bf99e0469810f943
出典データセット: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06284710B1

反応ノート

読み込み中…