関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | Benzenediazonium, 4-chloro-, hexafluorophosphate(1-) (1:1) | HCID 2723983 | — |
| 反応物 | 2-Amino-4-chloro-6-neopentylpyrimidine | HCID 22274982 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | 4-Chloro-2,5-diamino-6-neopentyl-pyrimidine | HCID 22274946 | — |
反応手順
A mixture of 2-amino-4-chloro-6-neopentylpyrimidine (1 mmol), sodium acetate (14 mmol), acetic acid (86 mmol), and 4-chlorobenzene-diazonium hexafluorophosphate (1.15 mmol) in water was stirred at 25° C. for 12 h. Extraction and evaporation gave a yellow solid which was treated with zinc dust (10 mmol) and acetic acid (5.54 mmol) in EtOH-H2O at 80° C. for 1 h. Extraction and chromatography gave 4-chloro-2,5-diamino-6-neopentyl-pyrimidine as a yellow solid. TLC: Rf=0.25, 50% EtOAc-hexane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06284748B1 |
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| 出典データセット | uspto-grants-2001_09 |
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| ORD ID | ord-92df3c8e89314e2e820f1a90cd808ab1 |
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| 出典メモ | uspto-grants-2001_09 |
|---|
