Hydrochloric Acid → 4-Biphenylylacetic acid methyl ester

HRID 1594680ノート

反応式

HRID 1594680 の反応式
[C:1]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][C:4]([CH2:7][C:8]([OH:10])=[O:9])=[CH:3][CH:2]=1.Cl.[CH3:18]O>>[CH3:18][O:9][C:8](=[O:10])[CH2:7][C:4]1[CH:3]=[CH:2][C:1]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:6][CH:5]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3332Felbinac

生成物 1

HCID 30808634-Biphenylylacetic acid methyl ester収率 98%

実験手順

To a solution of 4-biphenylacetic acid (10 g, 47 mmol) in methanol (150 mL) was added concentrated HCl (3 mL). The mixture was heated under reflux for 16 hours, cooled to rt, and the solvent was evaporated. Chromatography of the residue over silica gel (petroleum ether followed by ethyl acetate/petroleum ether 1/4) gave 4-biphenylacetic acid methyl ester (10.4 g, 98%).

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 16 hours
  3. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-89f6f13aa6804b27a5cefe72be011ca9
出典データセット
uspto-grants-2001_09
特許番号
US06284768B1

反応ノート

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