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Diisopropylamine → Bis(2,4,6-trimethylbenzoyl)-4-methylphenylphosphine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 2,4,6-Trimethylbenzoyl chloride | HCID 97038 | — |
| 反応物 | 4-Tolylphosphine | HCID 4379937 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | Bis(2,4,6-trimethylbenzoyl)-4-methylphenylphosphine | HCID 22623559 | — |
反応手順
A solution of 16.2 g of diisopropylamine in 50 ml of tetrahydrofuran (THF) is cooled to −10° C. 100 ml of butyllithium in hexane (1.6 M) are added dropwise. Then, at −40° C., first 9.0 g of 4-methylphenylphosphine and, subsequently, a solution of 29.22 g of 2,4,6-trimethylbenzoyl chloride in 150 ml of THF are added. The solution is stirred for 1.5 hours and then the solvent is removed under reduced pressure, to give 28.0 g of bis(2,4,6-trimethylbenzoyl)-4-methylphenylphosphine as a yellow powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06284813B1 |
| 出典データセット | uspto-grants-2001_09 |
| ORD ID | ord-adf7bb0480f841f2be562b323cc34ea1 |
| 出典メモ | uspto-grants-2001_09 |