{2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-tert-butyl Urea → {2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-urea
反応式
[C:1]([C:3]1[CH:25]=[CH:24][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][N:15](C(C)(C)C)[C:16]([NH2:18])=[O:17])=[CH:11][N:10]=[C:9]2[CH3:23])=[CH:5][C:4]=1[F:26])#[N:2]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[C:1]([C:3]1[CH:25]=[CH:24][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][NH:15][C:16]([NH2:18])=[O:17])=[CH:11][N:10]=[C:9]2[CH3:23])=[CH:5][C:4]=1[F:26])#[N:2]参加物
3
実験手順
{2-[3-(4-cyano-3-fluoro-benzyl)-2-methyl-3H-imidazol-4-yl]-ethyl}-tert-butyl urea (as described above in Step A) (0.41 g) was dissolved in TFA/CH2Cl2 3:1 (5.0 mL) and stirred at ambient temperature for 72 hr. The solvents were removed in vacuo to obtain the title compound.
後処理
- customThe solvents were removed in vacuo