Boron tribromide → HCID 21706300、化合物
反応式
B(Br)(Br)Br.C[O:6][C:7]1[CH:8]=[C:9]([C:13]2([CH2:21][CH2:22][CH3:23])[O:18][CH2:17][CH2:16][N:15]([CH3:19])[C:14]2=[O:20])[CH:10]=[CH:11][CH:12]=1>C(Cl)Cl>[OH:6][C:7]1[CH:8]=[C:9]([C:13]2([CH2:21][CH2:22][CH3:23])[O:18][CH2:17][CH2:16][N:15]([CH3:19])[C:14]2=[O:20])[CH:10]=[CH:11][CH:12]=1参加物
4
実験手順
BBr3 (1M in CH2Cl2) (0.341 mL, 0.341 mmol) was added dropwise to a solution of 2-(-3-methoxy-phenyl)-4-methyl-2-propyl-morpholine-3-one, as described above in Step D, (0.06 g, 0.227 mmol) in CH2Cl2 (3 mL) at 0° C. with stirring. The ice bath was removed and stirring was continued for 16 h. The reaction mixture was quenched with H2O, concentrated to dryness, then dissolved in MeOH and purified by RP preparative HPLC on a PrepPak (95/5 to 5/95 H2O/CH3CN w/0.1% TFA, flow=65 mL/min) to give the title compound. FAB MS (M+1) 250.