Diethyl acetamide 2-(4-octanoyl phenyl)ethyl malonate → Diethyl acetamide 2(4-octyl phenyl)ethyl malonate
反応式
[CH2:1]([CH:3]([CH2:7][CH3:8])[C:4]([NH2:6])=[O:5])[CH3:2].[C:9]([O:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24](=O)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:20][CH:19]=1)(=[O:14])[CH2:10][C:11]([O-:13])=[O:12]>C(O)C.[C].[Pd]>[CH2:1]([CH:3]([CH2:7][CH3:8])[C:4]([NH2:6])=[O:5])[CH3:2].[C:9]([O:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:20][CH:19]=1)(=[O:14])[CH2:10][C:11]([O-:13])=[O:12]参加物
4
実験手順
Diethyl acetamide-2-(4-octanoyl phenyl)ethyl malonate prepared in the step J (923 g) was stirred in ethanol (10 L) under atmosphere of hydrogen in the presence of 5% palladium carbon (138 g) overnight. The catalyst was removed by filtration, and the filtrate was concentrated. The residue was recrystallized from hexane to obtain diethyl acetamide-2(4-octyl phenyl)ethyl malonate (670 g) in the form of colorless crystal.