Benzylamine → HCID 21704006、化合物

HRID 1595318ノート

反応式

HRID 1595318 の反応式
[CH:1]1([C:7](=O)[C:8](=[N:16]O)[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1C=CC=CC=1>[CH:1]1([C:7]2[NH:26][C:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][C:8]=2[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 178451306HCID 178451306、化合物

生成物 1

HCID 21704006HCID 21704006、化合物収率 27.1%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

tert-Butyl 3-cyclohexyl-2-hydroxyimino-3-oxopropionate (2.6 g) and benzylamine (2.1 g) were dissolved in benzene (50 ml), and the mixture was refluxed under heating for 16 hr. The solvent was concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (chloroform:ethyl acetate=8:1) to give tert-butyl 5-cyclohexyl-2-phenylimidazole-4-carboxylate (0.90 g), melting point 222-223° C.

後処理

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 16 hr
  3. concentrationThe solvent was concentrated under reduced pressure
  4. customThe obtained residue was purified by silica gel chromatography (chloroform:ethyl acetate=8:1)

出典と根拠

ORDレコード
ord-2d2ec05359ab417f9b6a7f3bc42bc553
出典データセット
uspto-grants-2001_09
特許番号
US06288061B1

反応ノート

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