4-Nitrobenzylamine → HCID 178470203、化合物

HRID 1595339ノート

反応式

HRID 1595339 の反応式
O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[N+:18]([C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH2:26])=[CH:23][CH:22]=1)([O-:20])=[O:19]>>[CH3:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[NH:26][C:25]([C:24]3[CH:23]=[CH:22][C:21]([N+:18]([O-:20])=[O:19])=[CH:28][CH:27]=3)=[N:2][C:3]=2[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:12][CH:13]=1

参加物

3

反応物 2

HCID 291474-NitrobenzylamineHCID 178472891HCID 178472891、化合物

生成物 1

HCID 178470203HCID 178470203、化合物収率 77.7%

実験手順

Ethyl 2-hydroxyimino-3-(4-methylphenyl)-3-oxopropionate (50.0 g) and 4-nitrobenzylamine (50.0 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-methylphenyl)-2-(4-nitrophenyl)imidazole-4-carboxylate (58.0 g), which was dissolved in ethyl alcohol (1200 ml). Thereto was added 1 M sodium hydroxide solution (300 ml) and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-methylphenyl)-2-(4-nitrophenyl)imidazole-4-carboxyic acid (37.6 g), melting point 212° C. (decomposition).

後処理

  1. additiontreated in the same manner as

出典と根拠

ORDレコード
ord-2572276935694af69b45db38d2237f6b
出典データセット
uspto-grants-2001_09
特許番号
US06288061B1

反応ノート

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