(2-Nitrophenyl)methanamine → HCID 178470184、化合物

HRID 1595340ノート

反応式

HRID 1595340 の反応式
O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[N+:18]([C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][NH2:24])([O-:20])=[O:19]>>[CH3:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[NH:24][C:23]([C:22]3[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=3[N+:18]([O-:20])=[O:19])=[N:2][C:3]=2[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:12][CH:13]=1

参加物

3

反応物 2

HCID 423893(2-Nitrophenyl)methanamineHCID 178472891HCID 178472891、化合物

生成物 1

HCID 178470184HCID 178470184、化合物収率 18.3%

実験手順

Ethyl 2-hydroxyimino-3-(4-methylphenyl)-3-oxopropionate (12.8 g) and 2-nitrobenzylamine (8.6 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-methylphenyl)-2-(2-nitrophenyl)imidazole-4-carboxylate(3.5g). 3.0 g therefrom was dissolved in ethyl alcohol (100 ml) and 1 M sodium hydroxide solution (20 ml) was added. The mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-methylphenyl)-2-(2-nitrophenyl)imidazole-4-carboxyic acid (2.4 g), melting point 144° C. (decomposition).

後処理

  1. additiontreated in the same manner as

出典と根拠

ORDレコード
ord-53b119e6a87945e3bd7e4fe8179c0ddb
出典データセット
uspto-grants-2001_09
特許番号
US06288061B1

反応ノート

読み込み中…