Benzaldehyde, 4-(phenylmethoxy)- → Ethyl 2-(4-benzyloxyphenyl)-5-(4-chlorophenyl)imidazole-4-carboxylate

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[C:9](=[N:15]O)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[CH2:18]([O:25][C:26]1[CH:33]=[CH:32][C:29]([CH:30]=O)=[CH:28][CH:27]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C([O-])(=O)C.[NH4+:38]>>[CH2:18]([O:25][C:26]1[CH:33]=[CH:32][C:29]([C:30]2[NH:38][C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:15]=2)=[CH:28][CH:27]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

反応物 3

HCID 78109Benzaldehyde, 4-(phenylmethoxy)-

HCID 517165Ammonium Acetate

HCID 178472894HCID 178472894、化合物

生成物 1

HCID 178470216Ethyl 2-(4-benzyloxyphenyl)-5-(4-chlorophenyl)imidazole-4-carboxylate

実験手順

Ethyl 3-(4-chlorophenyl)-2-hydroxyimino-3-oxopropionate, 4-benzyloxybenzaldehyde and ammonium acetate are reacted and treated in the same manner as in Example 22 to give ethyl 2-(4-benzyloxyphenyl)-5-(4-chlorophenyl)imidazole-4-carboxylate. Ethyl 2-(4-benzyloxyphenyl)-5-(4-chlorophenyl)imidazole-4-carboxylate is reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 2-(4-benzyloxyphenyl)-5-(4-chlorophenyl)-imidazole-4-carboxylic acid. 2-(4-Benzyloxyphenyl)-5-(4-chlorophenyl) imidazole-4-carboxylic acid is reacted and treated in the same manner as in Example 1 to give 2-(4-benzyloxyphenyl)-5-(4-chlorophenyl)-N-(2-thiazolyl)imidazole-4-carboxamide.

後処理

additiontreated in the same manner as in Example 22

出典と根拠

ORDレコード: ord-2c215e5acc904f3ab31d94e9f2f065f7
出典データセット: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06288061B1

反応ノート

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