Acetic Anhydride → Methyl 4-acetoxyindole-2-carboxylate
反応式
[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:11]([O:13][CH3:14])=[O:12])[NH:6]2.[C:15](OC(=O)C)(=[O:17])[CH3:16]>CN(C)C1C=CN=CC=1>[C:15]([O:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:11]([O:13][CH3:14])=[O:12])[NH:6]2)(=[O:17])[CH3:16]参加物
4
反応条件
- 温度
- 80 °C
実験手順
Methyl 4-hydroxyindole-2-carboxylate (0.5 g) and 4-dimethylarninopyridine (50 mg) were dissolved in acetic anhydride (5 ml) and heated at 80° C. for 3 hours. The reaction was allowed to cool overnight to precipitate white crystals, which were filtered and dried in vacuo (0.44 g, 72%); NMR δ (CD3SOCD3) 2.34 (s, 3H), 3.85 (s, 3H), 6.80 (d, 1H), 7.06 (s, 1H), 7.23 (t, 1H), 7.29-7.35 (m, 1H), 12.1 (bs, 1H); M/z (−) 232 (M−H+).
後処理
- temperatureto cool overnight
- customto precipitate white crystals, which
- filtrationwere filtered
- customdried in vacuo (0.44 g, 72%)
出典と根拠
- ORDレコード
- ord-a04b51e18986443d9a4c9208e2589aad
- 出典データセット
- uspto-grants-2001_09
- 特許番号
- US06288103B1
反応ノート
読み込み中…