Ammonium Hydroxide → 4-[2-(4-Hydroxyphenyl)ethoxy]benzaldehyde

HRID 1595514ノート

反応式

HRID 1595514 の反応式
[OH-].[NH4+].C([O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][O:15][C:16]2[CH:21]=[CH:20][C:19]([CH:22]=[O:23])=[CH:18][CH:17]=2)=[CH:9][CH:8]=1)(=O)C>CO>[OH:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]([CH:22]=[O:23])=[CH:20][CH:21]=2)=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 217049564-[2-(4-Formylphenoxy)ethyl]phenyl acetate

生成物 1

HCID 217050114-[2-(4-Hydroxyphenyl)ethoxy]benzaldehyde収率 94.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Ammonium hydroxide was added to a solution of 2.0 g (7 mmole) 4-[2-(4-formylphenoxy)ethyl]phenyl acetate in methanol. When the starting material was consumed the solvent was evaporated in vacuo. 0.5 M hydrochloric acid was added and the product was extracted with diethyl ether and dichloromethane, dried, filtered and evaporated to give 1.6 g (yield 93%) of 4-[2-(4-hydroxyphenyl)ethoxy]benzaldehyde

後処理

  1. customWhen the starting material was consumed the solvent
  2. customwas evaporated in vacuo
  3. addition0.5 M hydrochloric acid was added
  4. extractionthe product was extracted with diethyl ether and dichloromethane
  5. customdried
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-b02891a67bec4b60bdbd7409b6d05336
出典データセット
uspto-grants-2001_09
特許番号
US06288096B1

反応ノート

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