反応式
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13](Cl)=[C:14]([C:19]#[N:20])[CH:15]=[N:16]2)=[CH:11][C:10]=1[O:22][CH3:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:24][C:25]1[CH:33]=[C:32]2[C:28]([CH2:29][CH2:30][NH:31]2)=[CH:27][CH:26]=1.Cl.N1C=CC=CC=1>COCCO>[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([NH:24][C:25]3[CH:33]=[C:32]4[C:28]([CH2:29][CH2:30][NH:31]4)=[CH:27][CH:26]=3)=[C:14]([C:19]#[N:20])[CH:15]=[N:16]2)=[CH:11][C:10]=1[O:22][CH3:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
実験手順
A solution of 586 mg (1.60 mM) of 7-benzyloxy-4-chloro-6-methoxy-quinoline-3-carbonitrile, 560 mg (1.70 mM) of 6-Aminoindolin dihydrchloride salt and 208 mg (1.80 mM) of pyridine hydrochloride in 13 ml of 2-methoxyethanol was refluxed for 3 hours. The reaction was allowed to cool to room temperature and the resulting solid was isolated and washed with excess ethanol and dried under vacuum at 80° C. The resulting solid was digested in 300 ml of ethanol and the volume was reduced to 100 ml. The solid was isolated from the hot solution and the digestion process was repeated a second time. The solid was once again isolated from the hot solution to yield 206 mg of 7-benzyloxy-4-(2,3-dihydro-1H-indol-6-ylamino)-6-methoxy-quinoline-3-carbonitrile as a tan solid.
後処理
- customthe resulting solid was isolated
- washwashed with excess ethanol
- customdried under vacuum at 80° C
- customThe solid was isolated from the hot solution
- customThe solid was once again isolated from the hot solution
出典と根拠
- ORDレコード
- ord-9f72e12a4af347d5898f3b25ec9aeb4b
- 出典データセット
- uspto-grants-2001_09
- 特許番号
- US06288082B1
関連ノート
読み込み中…