Piperidine → 4-(Piperidine-1-sulfonyl)benzonitrile
反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>C(Cl)Cl>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2]参加物
4
実験手順
A mixture of 4-cyanobenzenesulfonyl chloride (0.51 g, 2.5 mmol) and piperidine (0.60 mL, 517 mg, 6.04 mmol) in 10 mL methylene chloride was stirred overnight at ambient temperature. The organic layer was washed successively with water, 5% HCl and brine, dried (Na2SO4) and concentrated. The resulting white solid (0.61 g, 96%) was used with no further purification.
後処理
- washThe organic layer was washed successively with water, 5% HCl and brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated
- customThe resulting white solid (0.61 g, 96%) was used with no further purification
出典と根拠
- ORDレコード
- ord-3ea63601232a458b8b96d1ba92c2708f
- 出典データセット
- uspto-grants-2001_09
- 特許番号
- US06288228B1
反応ノート
読み込み中…