化工社化工社 化学情報印刷レポート · 研究参考用
1-Bromonaphthalene-2-carbaldehyde → (1-Bromonaphthalen-2-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromonaphthalene-2-carbaldehyde | HCID 76909 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (1-Bromonaphthalen-2-yl)methanol | HCID 13113200 | 92.3% |
反応手順
A solution of 1-bromo-2-naphthaldehyde (2.12 g, 8.91 mmol) in MeOH under N2 at 0° C. was treated with NaBH4 (0.51 g, 13.4 mmol), stirred for 15 minutes, quenched with acetone, and concentrated. Purification on silica gel with 5% ethyl acetate/CH2Cl2 provided 1.95 g (92%) of the desired compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06288261B1 |
| 出典データセット | uspto-grants-2001_09 |
| ORD ID | ord-6e3aac090eda42cfb50f990f50991962 |
| 出典メモ | uspto-grants-2001_09 |