Triethylamine → HCID 21705605、化合物
反応式
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1.C(N(CC)CC)C.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>C(Cl)Cl>[CH3:26][S:27]([OH:29])(=[O:1])=[O:28].[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=2)=[CH:9][CH:10]=1参加物
5
実験手順
To a solution of example 14A (150 mg, 0.63 mmol) in 6 mL CH2Cl2 at 0° C. was added triethylamine (127 mg, 1.26 mmol, 2 eq.) followed by methanesulfonyl chloride (108 mg, 0.94 mmol, 1.5 eq.). After stirring at ambient temperature for 4 h, the reaction mixture was concentrated and purified on silica gel with 25% EtOAc/hexanes to provide 185 mg (92%) of the desired compound as a white solid.