2-Fluoroaniline → Methyl 4-(2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

反応式

Cl[C:2]1[C:3]([C:10]([O:12][CH3:13])=[O:11])=[N:4][N:5]([CH3:9])[C:6](=[O:8])[CH:7]=1.[F:14][C:15]1[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=1[NH2:17]>>[F:14][C:15]1[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=1[NH:17][C:2]1[C:3]([C:10]([O:12][CH3:13])=[O:11])=[N:4][N:5]([CH3:9])[C:6](=[O:8])[CH:7]=1

参加物

反応物 2

HCID 95842-Fluoroaniline

HCID 57886211Methyl 4-chloro-1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

生成物 1

HCID 66674390Methyl 4-(2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate収率 61%

実験手順

The title compound was prepared in 61% yield by the procedure as previously described in Example 166 (step H) using methyl 4-chloro-1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate (109 mg, 0.54 mmol, prepared as previously described in Example 1 (steps A-G) and 2-fluoroaniline (0.053 mL, 0.54 mmol).

後処理

customprepared

出典と根拠

ORDレコード: ord-e3d3226b93d840e1a9ed91970ad037b0
出典データセット: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07732616B2

反応ノート

読み込み中…

参加物