Anisole → HCID 21701628、化合物
反応式
C1(OC)C=CC=CC=1.C(OC([N:19]1[CH2:24][CH2:23][N:22]([NH:25][C:26](=[O:34])[C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[CH2:21][CH2:20]1)=O)C1C=CC=CC=1.[BrH:35].C(O)(=O)C>>[BrH:35].[N:22]1([NH:25][C:26](=[O:34])[C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[CH2:21][CH2:20][NH:19][CH2:24][CH2:23]1参加物
4
実験手順
To a solution of 25% hydrogen bromide-acetic acid (30 ml) and anisole (1.6 ml) was added N-(4-benzyloxycarbonyl-1-piperazinyl)-p-fluorobenzamide (10 g) dropwise for 15 minutes under nitrogen atmosphere. The reaction mixture was stirred at ambient temperature for 3 hours. The resulting precipitate was collected and washed with diethyl ether (10 ml) to give N-piperazinyl-p-fluorobenzamide hydrobromide (10.2 g) as white hydroscopic solid.
後処理
- customThe resulting precipitate was collected