Ammonia → 3-Amino-4-fluorophenol

HRID 1596243ノート

反応式

HRID 1596243 の反応式
N.[F:2][C:3]1[CH:9]=[CH:8][C:7]([O:10]C(OC)=O)=[CH:6][C:4]=1[NH2:5]>CO>[F:2][C:3]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:4]=1[NH2:5]

参加物

4

反応物 2

HCID 222AmmoniaHCID 217015692-Fluoro-5-methoxycarbonyloxyaniline

生成物 1

HCID 135191803-Amino-4-fluorophenol収率 73%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Concentrated aqueous ammonia (15 ml) was added to a solution of 2-fluoro-5-methoxycarbonyloxyaniline (400 mg, 2.16 mmol) in methanol (10 ml). The mixture was stirred for 2 hours and most of the solvent was removed by evaporation. The resulting suspension was diluted with water, acidified to pH7 and extracted with ethyl acetate. The organic extracts were washed with water, dried (MgSO4) and solvent removed by evaporation to give 2-fluoro-5-hydroxyaniline (200 mg, 73%).

後処理

  1. customwas removed by evaporation
  2. additionThe resulting suspension was diluted with water
  3. extractionextracted with ethyl acetate
  4. washThe organic extracts were washed with water
  5. dry with materialdried (MgSO4) and solvent
  6. customremoved by evaporation

出典と根拠

ORDレコード
ord-ca1253032bf3453b8fcabf92739bff90
出典データセット
uspto-grants-2001_09
特許番号
US06291455B1

反応ノート

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