Carbon tetrabromide → 5-Fluoro-indolyl-3-propylbromide
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2CCCO.[C:15]([Br:19])(Br)(Br)Br.[C:20]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=C[CH:21]=1>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH:15]([Br:19])[CH2:20][CH3:21])=[CH:5]2参加物
5
実験手順
A solution of 3-(5-fluoro-1H-indol-3-yl)-propan-1-ol (Intermediate 6) prepared in accordance with the procedures set forth in Demerson et al., J. Med. Chem., 19:391-395 (1976). (25.4 g, 0.13 mol), carbon tetrabromide (65.5 g, 0.2 mol) and triphenylphosphine (52 g, 0.2 mol) in methylene chloride (156 ml) was allowed to stir for 2 hours. The solvent was evaporated and the product chromatographed (30% ethyl acetate-hexanes) to afford 33.5 g (99%) of product.
後処理
- customThe solvent was evaporated
- customthe product chromatographed (30% ethyl acetate-hexanes)
出典と根拠
- ORDレコード
- ord-ec8ed7e58b5a4b74bb5328dbd8945e5e
- 出典データセット
- uspto-grants-2001_09
- 特許番号
- US06291683B1
反応ノート
読み込み中…