Methyl 4-cyano-4-(3,4-dichlorophenyl)heptanedioate → Methyl 3-[5-(3,4-dichlorophenyl)-2-oxopiperid-5-yl]propionate
反応式
[C:1]([C:3]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)([CH2:10][CH2:11][C:12]([O-])=[O:13])[CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7])#[N:2]>COCCO.[Ni]>[Cl:22][C:17]1[CH:16]=[C:15]([C:3]2([CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7])[CH2:1][NH:2][C:12](=[O:13])[CH2:11][CH2:10]2)[CH:20]=[CH:19][C:18]=1[Cl:21]参加物
4
実験手順
40 g of the compound prepared in step A are dissolved in 500 ml of 2-methoxyethanol, 2 g of Raney nickel are added and the mixture is hydrogenated at 40° C. under atmospheric pressure for 3 days. It is filtered and evaporated to give the expected product in the form of an oil (39 g).
後処理
- filtrationIt is filtered
- customevaporated
出典と根拠
- ORDレコード
- ord-8b66d6f89b9a4ea798a4d9bdad87e0da
- 出典データセット
- uspto-grants-2001_09
- 特許番号
- US06291672B1
反応ノート
読み込み中…