Hydrochloric Acid → HCID 86757427、化合物

反応式

[ClH:1].[CH3:2][O:3][C@H:4]([CH3:7])[C:5]#[N:6].[CH2:8]([OH:10])[CH3:9]>>[ClH:1].[CH2:8]([O:10][C:5](=[NH:6])[C@H:4]([O:3][CH3:2])[CH3:7])[CH3:9]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 5702569(2R)-2-Methoxypropanenitrile

生成物 1

HCID 86757427HCID 86757427、化合物収率 100%

実験手順

Hydrogen chloride gas was passed into an icecold solution of (R)-2-methoxy-propionitrile (prepared according to the method of Example 1, Step A, 9.91 g, 116.5 mmol) in anhydrous ethanol (100 mL) until the solution was saturated with the gas. The reaction was stored in a refrigerator over night. The excess ethanol was removed under vacuum to obtain the title compound of Example 1, Step B as a deliquescent solid (19.5 g, 100% yield); [α]D+46.4 (c=1, methanol); 1H NMR (CDCl3, 300 MHz) δ1.4 (d, 3H), 3.4 (s, 1H), 3.7 (q, 2H), 4.8 (q, 1H), 6.2 (b, 1H).