4-Quinolinecarboxaldehyde → 1-(Quinolin-4-yl)ethanol

HRID 1597363ノート

反応式

HRID 1597363 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=[O:12])=[CH:3][CH:2]=1.[Li][CH3:14]>CCOCC>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]([OH:12])[CH3:14])=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 780724-QuinolinecarboxaldehydeHCID 178418348HCID 178418348、化合物

生成物 1

HCID 53147551-(Quinolin-4-yl)ethanol収率 64.9%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To 4-quinolinecarbaldehyde (2 g, 12.73 mmol) in 20 ml anhydrous ether, MeLi (1.4M, 10 ml, 13.9 mmol) was added dropwise over a period of five minutes at 0° C. The reaction mixture was stirred at room temperature tor 3 hours. The solution was partitioned between ether (20 ml) and water (10 ml). The organic layer was dried over sodium sulfate, filtered and concentrated to give 1.43 g (59%) of the product which was then used as such for the subsequent step.

後処理

  1. customThe solution was partitioned between ether (20 ml) and water (10 ml)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-6eb32150d70c41e5ad6cbef956406831
出典データセット
uspto-grants-2001_09
特許番号
US06294566B1

反応ノート

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