関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-Amino-3,5-dibromopyrazine | HCID 620004 | — |
| 反応物 | 6-(Aminomethyl)quinoline | HCID 1514384 | — |
| 溶媒 | Dichloromethane ethanol | HCID 21584144 | — |
| 生成物 | 6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine | HCID 45789418 | 49% |
反応手順
A mixture of quinolin-6-ylmethanamine (13 g, 82 mmol), 3,5-dibromopyrazin-2-amine (21 g, 82 mmol) and di-isopropylethylamine (16 mL, 89 mmol) was heated to 130° C. for five hours. The reaction was diluted with dichloromethane:ethanol (9:1) and the resulting suspension was filtered. The precipitate was washed sequentially with water and ether and air dried to afford 6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine (13 g, 49%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07732604B2 |
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| 出典データセット | uspto-grants-2010_06 |
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| ORD ID | ord-703ad39523e24c928d2fda038c7b0137 |
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| 出典メモ | uspto-grants-2010_06 |
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