Acetaldehyde → HCID 18929411、化合物

HRID 1598504ノート

反応式

HRID 1598504 の反応式
C([Li])CCC.Br[C:7]1[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=1[Cl:18].[CH:19](=[O:21])[CH3:20]>CCOCC>[Cl:18][C:8]1[CH:9]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:11]=[C:12]([Cl:13])[C:7]=1[CH:19]([OH:21])[CH3:20]

参加物

5

反応物 3

HCID 177AcetaldehydeHCID 12682564-Bromo-3,5-dichlorobenzotrifluorideHCID 178418339Butyllithium

生成物 1

HCID 18929411HCID 18929411、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒3 回

実験手順

To a mixture of 65.2 ml of n-butyllithium (1.61M in hexane) and 100 ml of anhydrous ether was added dropwise 29.3 g of 4-bromo-3,5-dichlorobenzotrifluoride (3) in 30 ml of anhydrous ether at -78° C., followed by stirring for 20 minutes. Subsequently, 6.2 ml of acetaldehyde in 50 ml of anhydrous ether was added dropwise to the mixture at the same temperature, followed by stirring at 0° C. Ice waster was added to the reaction mixture, followed by extraction with ether, drying over anhydrous magnesium sulfate and concentration under reduced pressure to give 23.5 g of the desired product in the form of a colorless oil (crude yield 90.7% ).

後処理

  1. stirringby stirring at 0° C
  2. additionIce waster was added to the reaction mixture
  3. extractionfollowed by extraction with ether
  4. dry with materialdrying over anhydrous magnesium sulfate and concentration under reduced pressure

出典と根拠

ORDレコード
ord-19fa225dfb0f4dbd96abb58ca7f5d241
出典データセット
uspto-grants-1998_04
特許番号
US05739083

反応ノート

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