関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-Butanesulfonyl chloride | HCID 75430 | — |
| 反応物 | 2-amino-5-[pyridazin-3(2H)-on-6-yl]indane | HCID 18929773 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-n-butylsulfonylamino-5-[pyridazin-3(2H)-on-6-yl]indane | HCID 18929802 | 72.9% |
反応手順
In 50 ml of dimethylformamide were dissolved 1.14 g of 2-amino-5-[pyridazin-3(2H)-on-6-yl]indane and 0.8 g of triethyl amine, and 1.25 g of n-butanesulfonyl chloride was added thereto. The mixture was stirred at 50° C for 30 minutes and then stirred at room temperature overnight. The solvent was removed, water was added to the residue, and crystals precipitated were collected by filtration. The resulting crystals were recrystallized from methanol to obtain 1.27 g of 2-n-butylsulfonylamino-5-[pyridazin-3(2H)-on-6-yl]indane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05739132 |
|---|
| 出典データセット | uspto-grants-1998_04 |
|---|
| ORD ID | ord-5af222c59385436a96b3c24993006ea6 |
|---|
| 出典メモ | uspto-grants-1998_04 |
|---|
