2-n-butylsulfonylamino-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indane → 2-n-butylsulfonylamino-5-[pyridazin-3(2H)-on-6-yl]indane

HRID 1598568

反応式

HRID 1598568 の反応式
Br.C(O)(=O)C.[CH2:6]([S:10]([NH:13][CH:14]1[CH2:22][C:21]2[C:16](=[CH:17][CH:18]=[C:19]([C:23]3[CH2:24][CH2:25][C:26](=[O:29])[NH:27][N:28]=3)[CH:20]=2)[CH2:15]1)(=[O:12])=[O:11])[CH2:7][CH2:8][CH3:9]>CS(C)=O>[CH2:6]([S:10]([NH:13][CH:14]1[CH2:22][C:21]2[C:16](=[CH:17][CH:18]=[C:19]([C:23]3[CH:24]=[CH:25][C:26](=[O:29])[NH:27][N:28]=3)[CH:20]=2)[CH2:15]1)(=[O:11])=[O:12])[CH2:7][CH2:8][CH3:9]

参加物

4

反応物 2

HCID 189297852-n-butylsulfonylamino-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indaneHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

生成物 1

HCID 189298022-n-butylsulfonylamino-5-[pyridazin-3(2H)-on-6-yl]indane収率 84.2%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

In 100 ml of a 25% hydrogen bromide-acetic acid solution was suspended 17.44 g of 2-n-butylsulfonylamino-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indane, and 3.6 ml of dimethylsulfoxide was added thereto. The mixture was stirred at room temperature for 1 hour. Then, the reaction mixture was poured into ice water, and crystals precipitated were collected by filtration and recrystallized from methanol to obtain 14.60 g of 2-n-butylsulfonylamino-5-[pyridazin-3(2H)-on-6-yl]indane.

後処理

  1. additionwas added
  2. customprecipitated
  3. filtrationwere collected by filtration
  4. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-ab0d83df1bca4f1a9057e2e360943eca
出典データセット
uspto-grants-1998_04
特許番号
US05739132

関連ノート

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