Ammonia → cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamine
反応式
[N:1]1([C@H:6]2[CH2:11][CH2:10][CH2:9][CH2:8][C@H:7]2[N:12](C(OC(C)(C)C)=O)[CH3:13])[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.N>>[N:1]1([C@H:6]2[CH2:11][CH2:10][CH2:9][CH2:8][C@H:7]2[NH:12][CH3:13])[CH2:2][CH2:3][CH2:4][CH2:5]1参加物
4
反応条件
- 温度
- 60 °C
実験手順
(±)-cis-2-Pyrrolidinyl-N-t-butyloxycarbonyl-N-methylcyclohexylamine (247 gm) was slowly added to 6M hydrochloric acid at 60° C. with vigorous stirring. The solution was stirred an additional 5 minutes at 60° C. and poured onto ice (200 gm). Excess concentrated aqueous ammonia was added and the mixture was extracted with methylene chloride. The combined extracts were dried (Na2SO4) and the solvent removed on a rotary evaporator. The residue was distilled (78° C. at 0.3 mm Hg) to give the product as a colorless oil.
後処理
- additionpoured onto ice (200 gm)
- extractionthe mixture was extracted with methylene chloride
- dry with materialThe combined extracts were dried (Na2SO4)
- customthe solvent removed on a rotary evaporator
- distillationThe residue was distilled (78° C. at 0.3 mm Hg)
出典と根拠
- ORDレコード
- ord-049a10d333614782a47d81578727c7e7
- 出典データセット
- uspto-grants-1998_04
- 特許番号
- US05739158
反応ノート
読み込み中…