1,4-Dichlorobutane → Diethyl tetrahydropyridazine-1,2-dicarboxylate
反応式
[N:1]([C:8](OCC)=O)([C:3]([O:5][CH2:6][CH3:7])=[O:4])[NH2:2].Cl[CH2:14][CH2:15][CH2:16]CCl.[OH-:19].[K+]>CN1CCN(C)C1=O>[N:1]1([C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH2:8][CH2:14][CH2:15][CH2:16][N:2]1[C:3]([O:5][CH2:6][CH3:7])=[O:19]参加物
5
実験手順
Into a 500-ml, four-necked flask equipped with a reflux condenser, a stirrer and a thermometer were charged 35.2 g (0.2 mole) of diethyl hydrazinedicarboxylate, 25.9 g (0.204 mole) of 1,4-dichlorobutane, 200 ml of 1,3-dimethylimidazolidinone and 22.4 g (0.4 mole) of potassium hydroxide, gradually warmed up to 50°-60° C. and aged for 3 hours. After completion of the reaction, the reaction mixture was cooled and filtered to remove the solid matters, after which the solvent was removed by distillation under reduced pressure. The residue obtained was distilled under reduced pressure (110° C./1 mmHg) to obtain 33.0 g of diethyl hexahydropyridazine-1,2-dicarboxylate. The yield was 72%.