Glycolic Acid → HCID 10849735、化合物

HRID 1599325ノート

反応式

HRID 1599325 の反応式
[NH2:1][C:2]1[C:3]([NH:15][CH3:16])=[N:4][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:7]=1.[C:17]([OH:21])(=O)[CH2:18]O>>[OH:21][CH2:17][C:18]1[N:15]([CH3:16])[C:3]2[C:2]([N:1]=1)=[CH:7][CH:6]=[C:5]([S:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[N:4]=2

参加物

3

反応物 2

HCID 757Glycolic AcidHCID 105137093-Amino-2-methylamino-6-phenylthiopyridine

生成物 1

HCID 10849735HCID 10849735、化合物収率 58.6%

実験手順

A procedure similar to that described in Preparation 43 was repeated, except that 2.62 g of 3-amino-2-methylamino-6-phenylthiopyridine (prepared as described in Preparation 89) and 2.58 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a gradient elution method, with mixtures of ethyl acetate and methanol in ratios ranging from 50:1 to 10:1 by volume as the eluent, to give 1.80 g of the title compound, melting at 119°-120° C.

後処理

  1. customA procedure similar to that described in Preparation 43
  2. customthat the product was purified by column chromatography through silica gel
  3. washa gradient elution method

出典と根拠

ORDレコード
ord-64b54b5bab8a49d5a5b12d6338645b92
出典データセット
uspto-grants-1998_04
特許番号
US05739345

反応ノート

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