Diethyl Ether → 3-(4-Chloro-1,2,5-thiadiazol-3-yl)-4-methylpyridine
反応式
[Cl:1][C:2]1[C:6]([C:7]2[CH:12]([CH3:13])[CH:11]=[CH:10][N:9](C(OC3C=CC=CC=3)=O)[CH:8]=2)=[N:5][S:4][N:3]=1.[S].CCOCC>C1C2C(CCCC2)CCC1>[Cl:1][C:2]1[C:6]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:12]=2[CH3:13])=[N:5][S:4][N:3]=1参加物
5
実験手順
To a solution of 3-(3-chloro-1,2,5-thiadiazol-4-yl)-4-methyl-1-phenoxycarbonyl-1,4-dihydropyridine (11.7 g, 35 mmol) in decalin (100 ml) was added sulfur (1.4 g, 43 mmol) and the reaction mixture was refluxed for 5 h. After cooling to room temperature, ether (100 ml) was added and the organic phases extracted with 1N HCl (2×75 ml). The aqueous phase was basified with NaOH(aq) and extracted with methylene chloride (2×100 ml). The methylene chloride phase was dried and evaporated to give solid title material in 5.47 g (74%) yield.
後処理
- temperaturethe reaction mixture was refluxed for 5 h
- extractionthe organic phases extracted with 1N HCl (2×75 ml)
- extractionextracted with methylene chloride (2×100 ml)
- dry with materialThe methylene chloride phase was dried
- customevaporated
- customto give solid title material in 5.47 g (74%)
- customyield
出典と根拠
- ORDレコード
- ord-6881b1fa71b94bce86a5f5cb946850df
- 出典データセット
- uspto-grants-1998_04
- 特許番号
- US05741788
反応ノート
読み込み中…