4-Methoxybenzylamine → 2-[2-(4-Methoxybenzylamino)pyridin-6-yl]ethanol
反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][OH:10])[N:3]=1.[CH3:11][O:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][NH2:18])=[CH:15][CH:14]=1>CCOC(C)=O.O>[CH3:11][O:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][NH:18][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][OH:10])[N:3]=2)=[CH:15][CH:14]=1参加物
5
実験手順
Chloropyridine 30-2 (150 mg, 0.95 mmol) and 4-methoxybenzylamine (4 mL, 31 mmol) were combined neat and heated in a sealed tube at 160° for 4 days. After diluting with EtOAc and water the pH was adjusted to 7 phases separated and the organic phase was washed with brine, dried (MgSO4) and concentrated. Flash chromatography (twice on silica, 50% and 40% EtOAc/hexane) provided 30-3 as a yellow semi-solid.
後処理
- temperatureheated in a sealed tube at 160° for 4 days
- customseparated
- washthe organic phase was washed with brine
- dry with materialdried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-eb714730124f4d339aab012cce525a21
- 出典データセット
- uspto-grants-1998_04
- 特許番号
- US05741796
反応ノート
読み込み中…