Sodium Methoxide → 5-(Azidomethyl)tetrahydro-3-thiophenethiol
反応式
[N:1]([CH2:4][CH:5]1[S:9][CH2:8][CH:7]([S:10]C(=O)C)[CH2:6]1)=[N+:2]=[N-:3].C[O-].[Na+]>CO>[N:1]([CH2:4][CH:5]1[S:9][CH2:8][CH:7]([SH:10])[CH2:6]1)=[N+:2]=[N-:3]参加物
4
実験手順
A 0° C. solution, under argon, of 0.279 g of product from Example 141 in 3 ml of dry methyl alcohol is treated with 0.35 ml of 4.35M sodium methoxide. After 2 hours, the reaction mixture is concentrated in vacuo and the residue purified by chromatography (silica gel: 0-5% diethyl ether/hexane) to give 0.0465 g of the desired product.
後処理
- concentrationthe reaction mixture is concentrated in vacuo
- customthe residue purified by chromatography (silica gel: 0-5% diethyl ether/hexane)
出典と根拠
- ORDレコード
- ord-bb0de9f976d041458d5c4b8df9dc3bc2
- 出典データセット
- uspto-grants-1998_04
- 特許番号
- US05744465
反応ノート
読み込み中…