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2-Methylbenzenesulfonic acid → HCID 178477164、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylbenzenesulfonic acid | HCID 6925 | — |
| 反応物 | 5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thioribofuranose | HCID 54268469 | — |
| 反応物 | HCID 178418634 | HCID 178418634 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 178477164 | HCID 178477164 | 67.1% |
反応手順
Two grams of 5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thioribofuranose (prepared according to J. A. Secrist et al., J. Med. Chem., 1992,35,533) is stirred with 0.456 g of thioacetic acid in 25 ml of methylene chloride and 0.0.025 g of toluenesulfonic acid for 68 hours. On workup the reactiion is adsorbed onto magnesium silicate and then flash chromatographed on silica gel to give 1.5 g of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05744465 |
| 出典データセット | uspto-grants-1998_04 |
| ORD ID | ord-9a47062e05234ee1bbafc129cfa78050 |
| 出典メモ | uspto-grants-1998_04 |