Imidazole → HCID 18926613、化合物

HRID 1600165ノート

反応式

HRID 1600165 の反応式
[CH3:1][N:2]([CH3:16])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=2)[NH:6][CH:5]=1.[NH:17]1C=CN=[CH:18]1>C1(C)C(C)=CC=CC=1>[N:2]1([CH2:3][C:4]2[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=3)[NH:6][CH:5]=2)[CH:16]=[CH:18][N:17]=[CH:1]1

参加物

4

反応物 2

HCID 795ImidazoleHCID 18882Indole, 3-((dimethylamino)methyl)-5-nitro-

生成物 1

HCID 18926613HCID 18926613、化合物収率 93.5%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A mixture of N,N-dimethyl-5-nitro-1H-indole-3-methanamine (J.Med, Chem, 9, 140,(1966)) (9.10 g) and imidazole (2.96 g) in xylene (120 ml) was heated under reflux for 2.5 hours and then cooled. The solid was filtered off, washed with ether and dried to give the title compound (9.40 g), m.p. 230°-232° C. (from ethyl acetate/methanol). Found: C,59.85; H,4.39; N,22.80. C12H10N4O2 requires: C,59.50; H,4.16; N,23.13%.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 2.5 hours
  3. temperaturecooled
  4. filtrationThe solid was filtered off
  5. washwashed with ether
  6. customdried

出典と根拠

ORDレコード
ord-dab7a92d21104d1abe9121c894b2b43a
出典データセット
uspto-grants-1998_04
特許番号
US05744488

反応ノート

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