Fumarate → 5-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

HRID 1600453ノート

反応式

HRID 1600453 の反応式
[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][CH:3]=1.[C:13]([O-])(=O)/C=C/C([O-])=O>>[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH2:8][N:9]([CH3:13])[CH2:10][CH2:11][CH:12]=2)=[N:4][CH:3]=1

参加物

3

反応物 2

HCID 5460307FumarateHCID 196125135-Methyl-2-(3-pyridyl)-thiazole

生成物 1

HCID 196124795-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

実験手順

The title compound was prepared from 88 (2.2 g, 0.013 mol) by the procedure described in Example 49. The crude free base obtained, 89, was converted to the title fumarate, 90. Yield: 0.8 g (0.0032 mol, 25%). M.P. 159°-160° C. Anal. (C12H16N2O2S)C, H, N.

後処理

  1. customThe crude free base obtained

出典と根拠

ORDレコード
ord-1f3d63b3d76045508493ba53e1f22655
出典データセット
uspto-grants-1999_11
特許番号
USRE036374

反応ノート

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