Triethylamine → HCID 178512421、化合物

反応式

[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH:15]3[CH2:20][CH2:19][CH:18](N)[CH2:17][CH2:16]3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CS[C:24](=[N:36][C:37]([O:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)=[O:38])[NH:25][C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27].C([N:49](CC)CC)C>CN(C)C=O>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][CH:15]3[CH2:16][CH2:17][CH:18]([N:25]([C:26]([O:28][CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[O:27])[C:24]([NH:36][C:37]([O:39][CH2:40][C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)=[O:38])=[NH:49])[CH2:19][CH2:20]3)[CH2:11][CH2:12]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

実験手順

A solution of trans-N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-cylohexylamine (0.43 g, 1.5 mmol), S-methyl-N,N'-dicarbobenzyloxy isothiourea (Nowak K. and Kania L., Rocz. Chem., 1969;43(11):1953-1960) (0.59 g, 1.65 mmol) and triethylamine (0.18 g, 1.8 mmol) in dimethylformamide (DMF) (50 mL) was stirred at room temperature 3 days. An additional amount of the starting amine (0.075 g, 0.26 mmol) was added, and the reaction mixture was allowed to stand one more day and then evaporated to dryness. The residue was recrystallized from Et2O-hexane to yield trans-N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]-cyclohexyl-N, N'-dicarbobenzyloxyguanidine 0.568 g (63%) white solid; mp 136-137° C.