関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 3'-Iodoacetanilide | HCID 87971 | — |
| 反応物 | 3-(3-Cyclopentyloxy-4-methoxyphenyl)-3-ethynylcyclohexan-1-one | HCID 15392007 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 3-(3-Acetamidophenylethynyl)-3-(3-cyclopentyloxy-4-methoxyphenyl)-cyclohexan-1-one | HCID 15859060 | 60% |
反応手順
To a solution of the compound from Example 3 (E1) (0.2 g, 0.64 mmol) and 3-acetamido-1-iodobenzene (0.17 g, 0.64 mmol) in triethylamine (5 mL) under an argon atmosphere was added trace tetrakis(triphenylphosphine)palladium(0), copper(I) iodide and triphenylphosphine. The mixture was heated at 80° C. for 0.3 h, was cooled to room temperature and was concentrated in vacuo. The residue was purified by flash chromatography, eluting with 1:1 hexanes/ethyl acetate, to provide the title compound as tan solid (0.17 g, 60%), m.p. 58-60° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05977122 |
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| 出典データセット | uspto-grants-1999_11 |
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| ORD ID | ord-2a60b84e8bd24d1eb987154ae90337d0 |
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| 出典メモ | uspto-grants-1999_11 |
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