Sulfuric Acid → Methyl 3-(4-hydroxyphenyl)benzoate

HRID 1600944ノート

反応式

HRID 1600944 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[C:22](=O)([O-])O.[Na+]>CO>[CH3:22][O:2][C:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)=[O:3]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 7224324'-Hydroxy-biphenyl-3-carboxylic acid

生成物 1

HCID 5097337Methyl 3-(4-hydroxyphenyl)benzoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Solid 3'-carboxybiphenyl-4-ol (1.5 g) was suspended in methanol (10 ml) and concentrated sulfuric acid (1 ml). The mixture was heated at reflux for 16 hours. After cooling, the mixture was basified by the addition of solid sodium hydrogen carbonate. The white solid which formed was filtered and washed with copious amounts of water to give the sub-title compound as a white solid (1.5 g).

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 16 hours
  3. temperatureAfter cooling
  4. customThe white solid which formed
  5. filtrationwas filtered
  6. washwashed with copious amounts of water

出典と根拠

ORDレコード
ord-dbef5c807bcf487797086022dff1f618
出典データセット
uspto-grants-1999_11
特許番号
US05977105

反応ノート

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