Methylamine → N-Methyl 6-((2R)-2-hydroxy-4-(3-pyridyl)-1-butoxy)naphthalen-2-yloxyacetamide

HRID 1600965ノート

反応式

HRID 1600965 の反応式
C[O:2][C:3](=O)[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:16][CH2:17][C@H:18]([OH:27])[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)[CH:12]=2)[CH:7]=1.[CH3:29][NH2:30]>CO>[CH3:29][NH:30][C:3](=[O:2])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:16][CH2:17][C@H:18]([OH:27])[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)[CH:12]=2)[CH:7]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 541642626-((2R)-2-Hydroxy-4-(3-pyridyl)-1-butoxy)naphthalen-2-yloxyacetic acid methyl ester

生成物 1

HCID 54489683N-Methyl 6-((2R)-2-hydroxy-4-(3-pyridyl)-1-butoxy)naphthalen-2-yloxyacetamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 6-((2R)-2-hydroxy-4-(3-pyridyl)-1-butoxy)naphthalen-2-yloxyacetic acid methyl ester (0.215 g) in methanol (10 ml) was saturated with methylamine gas. After 16 hours the crystalline product was collected by filtration and dried under vacuum to give the title compound as a solid (0.10 g).

後処理

  1. filtrationAfter 16 hours the crystalline product was collected by filtration
  2. customdried under vacuum

出典と根拠

ORDレコード
ord-4865a5ec60584353a5005cd9bbf9ff21
出典データセット
uspto-grants-1999_11
特許番号
US05977105

反応ノート

読み込み中…