Boron tribromide → 2-Fluoro-4-phenylphenol
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[O:8]C.B(Br)(Br)Br>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[OH:8]参加物
4
実験手順
Prepared according to the method described in example 36b) from 3-fluoro-4-methoxybiphenyl (0.99 g), boron tribromide (1.0 M in dichloromethane, 9.8 ml) and dichloromethane (15 ml). After work up the residue was purified by column chromatography over silica eluting with dichloromethane:ethanol (19:1) to give the sub-title compound as a pale yellow crystalline solid (0.52 g).
後処理
- customPrepared
- customAfter work up the residue was purified by column chromatography over silica eluting with dichloromethane:ethanol (19:1)
出典と根拠
- ORDレコード
- ord-b755593322fa49bcab175ff7a728782a
- 出典データセット
- uspto-grants-1999_11
- 特許番号
- US05977105
反応ノート
読み込み中…