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Acetic Acid → 2-Aminoethylbenzimidazole diacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 1H-Benzimidazole-2-acetonitrile | HCID 20455 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | 2-Aminoethylbenzimidazole diacetate | HCID 85740009 | 95% |
反応手順
A mixture containing 2-cyanomethylbenzimidazole (2.0 g, 12.7 mmol), 10% Pd/C (1.0 g), and AcOH (40 mL) was hydrogenated at 42 psi for 6 h in a Parr apparatus. The reaction mixture was filtered through a bed of Celite® and concentrated to give the title compound (3.4 g, 95%): 1H NMR (250 MHz, CDCl3) δ 7.04-28.13 (m, 7H), 3.17-3.39 (m, 4H); MS (ES) m/e 162.0 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05977101 |
| 出典データセット | uspto-grants-1999_11 |
| ORD ID | ord-90a52a89dc02470caff06ce6db792efc |
| 出典メモ | uspto-grants-1999_11 |