Triethylamine → N-(3-chloropropyl)-4-nitrobenzamide

関与物質

反応手順

A solution of 6.43 g (49 mmol) 3-chloropropylamine and 13.6 ml (98 mmol) triethylamine in 220 ml methylene chloride was cooled by an ice bath and 9 g (48.5 mmol) 4-nitrobenzoyl chloride were added fractionwise. After one hour stirring at room temperature the organic phase was washed twice with water, dried over MgSO4 and concentrated in vacuo to afford 10.68 g (91%). of beige crystals. 1H NMR was consistent with the desired structure.

情報源と証拠