Glycolic Acid → (5-ethoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol

HRID 1601867ノート

反応式

HRID 1601867 の反応式
[NH2:1][C:2]1[C:3]([NH:11][CH3:12])=[N:4][C:5]([O:8][CH2:9][CH3:10])=[CH:6][CH:7]=1.[C:13]([OH:17])(=O)[CH2:14]O>>[CH2:9]([O:8][C:5]1[N:4]=[C:3]2[N:11]([CH3:12])[C:14]([CH2:13][OH:17])=[N:1][C:2]2=[CH:7][CH:6]=1)[CH3:10]

参加物

3

反応物 2

HCID 757Glycolic AcidHCID 10583205HCID 10583205、化合物

生成物 1

HCID 10560253(5-ethoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol収率 62.2%

実験手順

A procedure similar to that described in Preparation 43 was repeated, except that 4.15 g 3-amino-6-ethoxy-2-methylaminopyridine (prepared as described in Preparation 97), and 5.66 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, to give 3.20 g of the title compound, melting at 161° C.

後処理

  1. customA procedure similar to that described in Preparation 43
  2. customthat the product was purified by column chromatography through silica gel
  3. additionby volume mixture of ethyl acetate and methanol as the eluent

出典と根拠

ORDレコード
ord-cb4357bfdc60468683f4d6371c3214bb
出典データセット
uspto-grants-1999_11
特許番号
US05977365

反応ノート

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